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You are now taking an FDA-approved medication proven safe and effective for long-term use and is well tolerated. Presently, serotonin-enhancing drugs are the therapeutic regimens for those who are suspect of having a depressed state or mood disorder. Even if you begin to feel better, it is important to take Paxil and talk to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight.