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The effects of either could be increased, decreased, or altered. The digestive system. Zithromax is an azalide antibiotic, a subclass of the macrolides. Antibiotics which works by stopping the growth of bacteria. In sexually transmitted diseases in men and women, Azithromycin is indicated in the treatment of uncomplicated genital infections. Taking this medicine at the same time as antacids that contain aluminum or magnesium. In men and women, Azithromycin is indicated in the treatment of uncomplicated genital infections.